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ea0070oc1.7 | Adrenal and Cardiovascular Endocrinology | ECE2020

Comparative proteomic analysis of different bilateral adrenocortical hyperplasia

Berthon Annabel , Cologna Stephanie , Blank Paul , Hannah-Shmouni Fady , Bertherat Jerome , Porter Forbes , Stratakis Constantine

Bilateral Adrenal Hyperplasias (BAH) are responsible for approximately 10% of ACTH-independent Cushing syndrome and are classified as either micronodular or macronodular. Whereas Primary Pigmented Nodular Adrenocortical Disease (PPNAD) and isolated Micronodular Adrenal Disease (iMAD) are two types of micronodular hyperplasia, Primary Macronodular Adrenal Hyperplasia (PMAH) is a macronodular BAH. These tumors are classified differently based on clinical, histological and geneti...